Research

Chris has a longstanding interest in medical and neurosurgical research and is actively involved in ongoing research. His research interests span clinical neurosurgery with presentations and publications ranging from the investigations of adult stem cells in the treatment of intervertebral disc degeneration to the role of databases in optimising spine surgery quality improvement.

 
 

Chris aims to foster improved outcomes for his patients by contributing to research into advancing neurosurgical care.

 
 

Recent Publications & Presentations

 
  • Streijger F, Kim KT, So K, Manouchehri N, Shortt K, Okon EB, Morrison C, Fong A, Gupta R, Brown AA, Tigchelaar S, Sun J, Liu E, Keung M, Daly CD, Cripton PA, Sekhon MS, Griesdale DE, Kwon BK. Duraplasty in Traumatic Thoracic Spinal Cord Injury: Impact on Spinal Cord Hemodynamics, Tissue Metabolism, Histology, and Behavioral. J. Neurotrauma 2021 Jun 18. DOI: 10.1089/neu.2021.0084

    Tan D, Lai LT, Daly CD, Tran V, Maingard J, Timms C. Spinal Pleomorphic Xanthoastrocytoma: Case Report and Literature Review. World Neurosurg. (2020) Sep; 141:25-32. doi.org/10.1016/j.wneu.2020.05.117

    Tan D, Daly C, Xenos C, Lai LT, Chandra RV. Glioblastoma Presenting as Spontaneous Subarachnoid Hemorrhage: Technical Case Note of Combined Endovascular and Microsurgical Vision-Sparing Treatment. Word Neurosurg. (2019) 128:426-430. doi.org/10.1016/j.wneu.2019.05.090

    Lim KZ, Daly C, Brown J, Goldschlager T. Dynamic Posture-Related Preoperative Pain as a Single Clinical Criterion in Patient Selection for Extreme Lumbar Interbody Fusion with Direct Decompression. Global Spine J. Advanced online publication first published 15 Nov 2018. DOI:10.1177/219256821881317

    Sher I, Daly C Oehme D Chandra RV, Sher M, Ghosh P, Smith J, Goldschlager T. Novel Application of the Pfirmmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI. Spine (Phila Pa 1976). 2019 Jul 1;44(13):E766-E773. doi: 10.1097/BRS.0000000000002967.

    Sher I, Daly C Oehme D Chandra RV, Sher M, Ghosh P, Smith J, Goldschlager T. To The Editor. Spine (Phila Pa 1976). 2019 May 15;44(10):E630-E631. doi: 10.1097/BRS.0000000000003026.

    Sher I, Chandra RV, Daly C, Oehme D, Sher M, Smith J, Goldschlager T. 9.4T MRI Assessment of Degenerative Disc Disease: Statistical Methodology. Spine (Phila Pa 1976). 2019 Mar 4. doi: 10.1097/BRS.0000000000003026. [Epub ahead of print]

    Daly CD, Ghosh P, Badal T, Shimmon R, Jenkin G, Oehme D, Cooper-White J, Sher I, Chandra RV, Goldschlager T. A Comparison of Two Ovine Lumbar Intervertebral Disc Injury Models for the Evaluation and Development of Novel Regenerative Therapies. Global Spine J. 2018 Dec;8(8):847-859. doi: 10.1177/2192568218779988. Epub 2018 Jun 10.

    Sher I, Daly C Oehme D Chandra RV, Sher M, Ghosh P, Smith J, Goldschlager T. Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI. Spine (Phila Pa 1976). 2018 Dec 11. doi: 10.1097/BRS.0000000000002967. [Epub ahead of print]

    Daly CD, Lim KZ, Ghosh P, Goldschlager T. Perioperative care for lumbar microdiscectomy: a survey of Australasian neurosurgeons. J Spine Surg. 2018 Mar;4(1):1-8.

    Wu J, Shimmon S, Paton S, Daly C, Goldschlager T, Gronthos S, Zannettino ACW, Ghosh P. Pentosan polysulfate binds to STRO-1+ mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programming stem cells for therapeutic application requiring their chondrogenesis. Stem Cell Res Ther. 2017 Dec 13;(1):278.

    Daly CD, Ghosh P, Zannettino ACW, Badal T, Shimmon R, Jenkin G, Oehme D, Jain K, Sher I, Vais A, Cohen C, Chandra RV, Goldschlager T. Mesenchymal progenitor cells primed with pentosane polysulfate promote lumbar intervertebral disc regeneration in an ovine model of microdiscectomy. Spine J. 2018 Mar;18(3):491-506.

    Daly CD, Lim KZ, Lewis J, Saber K, Molla A, Bar-Zeev N, Goldschlager T. Lumbar microdiscectomy and post-operative activity restrictions: a protocol for a single blinded randomised controlled trial. BMC Musculoskelet Disord. 2017 Jul 20;18(1):312.

    Lim KZ, Daly CD, Ghosh P, Jenkin G, Oehme D, Cooper-White J, Naidoo T, Goldschlager T. Ovine lumbar intervertebral disc degeneration model utilizing a lateral retroperitoneal drill bit injury. J Vis Exp. 2017 May 25;(123).

    Daly C, Ghosh P, Jenkin G, Oehme D, Goldschlager T. A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic. Biomed Res Int 2016;(3):5952165.

    Daly CD, Campbell GR, Walker PJ, Campbell JH. (2005) Vascular engineering for bypass surgery. Expert Rev of Cardiovascular Ther. 2005 Jul;3(4):659-65.

    Daly CD, Campbell GR, Walker PJ and Campbell JH. (2004) In vivo engineering of blood vessels. Front Biosci. 2004 May 1;9:1915-24.

  • Daly CD, Campbell GR, Campbell JH. Tissue engineering of arteries. Cardiovascular Research: New Technologies, Methods and Applications. Editors: G Pasterkamp, DPV de Kleijn. Springer Publishers. 2005. 207-219.

    Daly, C and Goldschlager, T. Chapter 24: Surgical versus Nonsurgical Therapy for Lumbar Spinal Stenosis in 50 Landmark Papers Every Spine Surgeons Should Know. Editors: Vacarro AR, Wilson JR, Fisher CG. CRC Press. 2018. 123-126.

  • Daly, C.D., Nevin, J., Bourassa-Moreau, E., Dvorak, M.F., Fisher, C.G., Paquette, S., Kwon, B.K., Dea, N., Ailon, T, Charest-Morin, R., Street, J.T. Comparison of a general (NSQIP) and spine specific (SAVES) database for the identification of spine surgery acute care adverse events. Presented at the Canadian Spine Society 21st Annual Scientific Virtual Conference February 2021 Ontario, Canada.

    Sher I, Sher A, Daly C, Oehme D, Ghosh P, Fulcher A, Chandra RV, Smith J, Goldschlager T. High Resolution Imaging with 9.4T MRI and Complementary Specialised Microscopy Provides New Insights Into The Structure Of The Intervertebral Disc. Presented at the Global Spine Congress Singapore 2018.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Sher I, Vais A, Cohen C, Goldschlager T. Pentosan polysulfate primed mesenchymal progenitor cells promote intervertebral disc repair following microdiscectomy in an ovine model. Presented at the Monash Health Translation Precinct Research Week, November 2017, Melbourne, Australia.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Sher I, Vais A, Cohen C, Goldschlager T. Pentosan polysulfate primed mesenchymal progenitor cells promote intervertebral disc repair following microdiscectomy in an ovine model. Presented at the North American Spine Society 32nd Annual Meeting, October 2017, Orlando USA.

    Sher I, Oehme D, Daly CD, Chandra RV, Sher M, Fulcer A, Cohen C, Vais A, Smith JA, Goldschlager T. Histological, Radiological, Immuno-Histochemical and Birefringence Investigation of the Mechanisms of Action of Mesenchymal Progenitor Stem Cells (MPCs) in the Early Repair of Degenerative Disc Disease Using the Ovine Annulotomy Injury Model. Presented at the North American Spine Society 32nd Annual Meeting, October 2017, Orlando USA.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Sher I, Vais A, Cohen C, Goldschlager T. Intervertebral disc repair following microdiscectomy mediated by pentosan polysulafte primed mesenchymal progenitor cells in an ovine model. Presented at the Congress of Neurological Surgeons 2017 Annual Meeting, October 2017, Boston USA.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Sher I, Vais A, Cohen C, Goldschlager T. Pentosan polysulfate primed mesenchymal progenitor cells promote intervertebral disc repair following microdiscectomy in an ovine model. Presented at the Neurosurgical Society of Australasia Annual Scientific Meeting 2017 Adelaide, Australia.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Sher I, Vais A, Cohen C, Goldschlager T. Mesenchymal progenitor cells primed with pentosane polysulfate mediate disc repair following microdiscectomy in an ovine model. Presented at the Global Spine Congress, May 2017, Milan.

    Sher I, Daly C, Goldschlager T, Oehme D, Chandra R, Ghosh P. 9.4T MRI complements the Pfirrmann grade through better differentiation of the NP/AF. Presented at the Global Spine Congress, May 2017, Milan.

    Daly CD, Ghosh P, Badal T, Shimmon R, Ghosh I, Jenkin G, Oehme D, Cooper-White J, Naidoo T, Sher I, Jain K, Oehme D, Goldschlager T. Radiological, Histological, Morphological and Biochemical Comparison of two Ovine Lumbar Intervertebral Disc Injury Models. Presented at the Global Spine Congress, May 2017, Milan.

    Sher I, Sher M, Daly C, Fulcher A, Oehme D, Ghosh P, Smith J, Goldschlager T. Detailed analysis of intervertebral disc structure using the 9.4T MRI and polarized light microscopy facilitates understanding of disc biomechanics. Presented at the Spine Society of Australia Annual Scientific Meeting 2017, Hobart.

    David Oehme, Peter Ghosh, Tony Goldschlager, Courtney McDonald, Chris Daly, John Troupis, Jeffrey V. Rosenfeld, Graham Jenkin. Disc Regeneration Using STRO-3+ Immunoselected Allogeneic Mesenchymal Precursor Cells Combined with Pentosan Polysulfate. NSA Sydney Oct 2016.

    Daly C, Goldschlager T, Ghosh P, Jenkin G, Cooper-White J and Naidoo T. Radiological, Histological and Biochemical Characterization of a Novel Ovine Lumbar Intervertebral Disc Injury Model. Presented at the World Forum for Spine Research Dubai 2016.

    K. Lim, Troupis J, Daly C, Oehme D and Goldschlager T. Indications for Use of Dynamic Four-dimensional Computed Tomography in Diagnosing Instability in Spinal Cervical Conditions. Presented at the Global Spine Congress Dubai 2016.

    Daly C, Oehme D, Ghosh P, Goldschlager, Rosenfeld J, Troupis J, MCDonald C, Jenkin G. Mesenchymal progenitor cells combined with pentosan polysulfate can mediate disc regeneration at the time of microdiscectomy. Presented at the XIIth annual Adelaide Centre for Spinal Research Symposium Adelaide 2014

  • Daly, C.D., Nevin, J., Bourassa-Moreau, E., Dvorak, M.F., Fisher, C.G., Paquette, S., Kwon, B.K., Dea, N., Ailon, T, Charest-Morin, R., Street, J.T. Comparison of a general (NSQIP) and spine specific (SAVES) database for the identification of spine surgery acute care adverse events. Presented at the AOSpine Virtual Fellows Forum 2021, Banff, Canada.

    Daly C, Sher I, Ghosh P, Badal T, Shimmon R, Jenkin G, Oehme D, Chandra R, Goldschlager T. The Correlation of 9.4T MRI Nucleus Pulposus/Annulus Fibrosus Distinction With Biochemical Markers of Intervertebral Disc Degeneration. Presented at the Global Spine Congress Singapore 2018.

    Sher I, Daly CD, Oehme D, Chandra RV, Ghosh P, Sher M, Smith JA, Goldschlager T. Could the Transitional Zone be the Key to Predicting Degenerative Disc Disease? Presented at the North American Spine Society 32nd Annual Meeting, October 2017, Orlando USA.

    Daly CD, Lim KZ, Ghosh P, Lewis J, Saber K, Buchanan M, Goldschlager T. Post-operative-care following lumbar microdiscectomy: a survey of Australasian Neurosurgeons. Presentation at the Global Spine Congress 2017, Milan.

    Daly CD and Tan L. Pilomatrix carcinoma of the cervical spine: Case report and review of the literature. Presented at the 2011 NSA Annual Scientific Meeting Fiji.

    Daly CD, Campbell GR, Walker PJ, Cong H-L, Xiang L and Campbell JH. Development of a peritoneal implant mold for tissue engineering of arteries. Presented at the 8th Annual Hilton Head Workshop, Hilton Head, South Carolina, USA 6th-10th March 2004.